DSIP

Overview

DSIP, delta sleep inducing peptide, is a nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. It was first isolated in the 1970s from the cerebral venous blood of rabbits during induced slow wave sleep, which is where the name comes from. What makes it unusual in a peptide catalogue is how little has been settled about it: after half a century of study its mechanism remains poorly resolved and no specific receptor has been established. It persists in the literature as an open question rather than as a settled tool compound, and that is largely the reason researchers continue to order it.

Areas of research interest

The points below describe where this material, or the compound class it belongs to, appears in the published scientific literature. They are provided to help researchers scope a study design. They are not claims about what this product does and no outcome of any kind is represented.

• Sleep architecture and circadian research in preclinical models
• Receptor identification and binding site characterisation work
• Neuroendocrine signalling studies
• Analytical characterisation and stability of short endogenous nonapeptides

Specifications

Handling, reconstitution and storage

• Store sealed vials at -20 °C, protected from light. Short excursions to 2 to 8 °C in transit are expected; return vials to frozen storage on receipt.
• Reconstitute with bacteriostatic water or another diluent appropriate to your protocol. Add the diluent slowly against the inner wall of the vial and allow the cake to dissolve without agitation. Do not shake.
• After reconstitution, store at 2 to 8 °C and protect from light. Establish an in-use period from your own stability testing rather than from a supplier figure.
• Avoid repeated freeze-thaw cycles. Aliquot where a protocol calls for multiple withdrawals from a single vial.
• Use aseptic technique and standard personal protective equipment throughout. Allow vials to reach room temperature before opening to limit condensation.

Certificate of Analysis

Every lot is supplied with its own Certificate of Analysis. Identity, content and purity figures are those stated on that document for the specific lot supplied, and researchers should verify identity and suitability against their own analytical methods before the material is put into a study.

Research use only

This product is supplied strictly for laboratory research use only. It is not a drug, food, cosmetic or dietary supplement. It is not intended to diagnose, treat, cure or prevent any disease, and it is not intended for human or veterinary consumption or for administration to humans or animals in any form. It must be handled only by qualified researchers in an appropriate laboratory setting, and it is the purchaser who is responsible for ensuring that their intended use complies with all laws and institutional requirements that apply to them.