Cagrilintide

Overview

Cagrilintide is a long acting synthetic analogue of amylin, the 37 amino acid hormone co-secreted with insulin from pancreatic beta cells. Native amylin is notoriously difficult to work with because it aggregates readily into amyloid fibrils, which makes reproducible handling a problem before any experiment begins. The analogue carries sequence modifications together with a lipid side chain that address both the aggregation behaviour and the very short half life of the parent hormone. It appears in the literature as a tool for amylin receptor pharmacology, where the receptors of interest are heteromers of the calcitonin receptor with receptor activity modifying proteins.

Areas of research interest

The points below describe where this material, or the compound class it belongs to, appears in the published scientific literature. They are provided to help researchers scope a study design. They are not claims about what this product does and no outcome of any kind is represented.

• Amylin receptor pharmacology, including calcitonin receptor and RAMP heteromer binding
• Comparative work against native amylin and other analogues
• Peptide aggregation and amyloid fibril formation studies
• Analytical characterisation of lipidated peptide analogues

Specifications

Handling, reconstitution and storage

• Store sealed vials at -20 °C, protected from light. Short excursions to 2 to 8 °C in transit are expected; return vials to frozen storage on receipt.
• Reconstitute with bacteriostatic water or another diluent appropriate to your protocol. Add the diluent slowly against the inner wall of the vial and allow the cake to dissolve without agitation. Do not shake.
• After reconstitution, store at 2 to 8 °C and protect from light. Establish an in-use period from your own stability testing rather than from a supplier figure.
• Avoid repeated freeze-thaw cycles. Aliquot where a protocol calls for multiple withdrawals from a single vial.
• Use aseptic technique and standard personal protective equipment throughout. Allow vials to reach room temperature before opening to limit condensation.

Certificate of Analysis

Every lot is supplied with its own Certificate of Analysis. Identity, content and purity figures are those stated on that document for the specific lot supplied, and researchers should verify identity and suitability against their own analytical methods before the material is put into a study.

Research use only

This product is supplied strictly for laboratory research use only. It is not a drug, food, cosmetic or dietary supplement. It is not intended to diagnose, treat, cure or prevent any disease, and it is not intended for human or veterinary consumption or for administration to humans or animals in any form. It must be handled only by qualified researchers in an appropriate laboratory setting, and it is the purchaser who is responsible for ensuring that their intended use complies with all laws and institutional requirements that apply to them.