PT-141

Overview

PT-141, bremelanotide, is a metabolite of melanotan II in which the C terminal amide is replaced by a carboxylic acid. That single change shifts the selectivity profile towards the melanocortin 4 receptor and away from the MC1R mediated pigmentation activity of the parent molecule. Its place in the literature follows directly from that: it is the melanocortin analogue reached for when central MC4R signalling is the subject of the experiment and pigmentation activity would be a confounding variable rather than the thing being measured.

Areas of research interest

The points below describe where this material, or the compound class it belongs to, appears in the published scientific literature. They are provided to help researchers scope a study design. They are not claims about what this product does and no outcome of any kind is represented.

• Melanocortin 4 receptor binding and functional assays
• Central melanocortin signalling research in preclinical models
• Comparative work against melanotan II to separate MC4R from MC1R activity
• Structure activity studies on C terminal modification of melanocortin peptides

Specifications

Handling, reconstitution and storage

• Store sealed vials at -20 °C, protected from light. Short excursions to 2 to 8 °C in transit are expected; return vials to frozen storage on receipt.
• Reconstitute with bacteriostatic water or another diluent appropriate to your protocol. Add the diluent slowly against the inner wall of the vial and allow the cake to dissolve without agitation. Do not shake.
• After reconstitution, store at 2 to 8 °C and protect from light. Establish an in-use period from your own stability testing rather than from a supplier figure.
• Avoid repeated freeze-thaw cycles. Aliquot where a protocol calls for multiple withdrawals from a single vial.
• Use aseptic technique and standard personal protective equipment throughout. Allow vials to reach room temperature before opening to limit condensation.

Certificate of Analysis

Every lot is supplied with its own Certificate of Analysis. Identity, content and purity figures are those stated on that document for the specific lot supplied, and researchers should verify identity and suitability against their own analytical methods before the material is put into a study.

Research use only

This product is supplied strictly for laboratory research use only. It is not a drug, food, cosmetic or dietary supplement. It is not intended to diagnose, treat, cure or prevent any disease, and it is not intended for human or veterinary consumption or for administration to humans or animals in any form. It must be handled only by qualified researchers in an appropriate laboratory setting, and it is the purchaser who is responsible for ensuring that their intended use complies with all laws and institutional requirements that apply to them.