CJC-1295 No DAC / Ipamorelin

Overview

This preparation combines CJC-1295 without DAC, also catalogued as Modified GRF (1-29), with ipamorelin in a single lyophilised vial. CJC-1295 without DAC is a 29 amino acid GHRH analogue carrying four amino acid substitutions that improve its resistance to enzymatic degradation, and unlike the version bearing a drug affinity complex it has no albumin binding component, which gives it a much shorter working profile. Pairing a GHRH analogue with a GHS-R1a agonist is a long standing arrangement in the literature because the two act through separate receptors, and a combination vial exists so both can be introduced in a single reconstitution. The content attributable to each component is stated on the Certificate of Analysis for the lot supplied.

Areas of research interest

The points below describe where this material, or the compound class it belongs to, appears in the published scientific literature. They are provided to help researchers scope a study design. They are not claims about what this product does and no outcome of any kind is represented.

• Parallel receptor engagement studies across GHRH and GHS-R1a pathways
• Pituitary cell culture models examining combined secretagogue signalling
• Comparative work against each component supplied as a separate reference item
• Analytical method development for resolving two peptides in one preparation

Specifications

Handling, reconstitution and storage

• Store sealed vials at -20 °C, protected from light. Short excursions to 2 to 8 °C in transit are expected; return vials to frozen storage on receipt.
• Reconstitute with bacteriostatic water or another diluent appropriate to your protocol. Add the diluent slowly against the inner wall of the vial and allow the cake to dissolve without agitation. Do not shake.
• After reconstitution, store at 2 to 8 °C and protect from light. Establish an in-use period from your own stability testing rather than from a supplier figure.
• Avoid repeated freeze-thaw cycles. Aliquot where a protocol calls for multiple withdrawals from a single vial.
• Use aseptic technique and standard personal protective equipment throughout. Allow vials to reach room temperature before opening to limit condensation.

Certificate of Analysis

Every lot is supplied with its own Certificate of Analysis. Identity, content and purity figures are those stated on that document for the specific lot supplied, and researchers should verify identity and suitability against their own analytical methods before the material is put into a study.

Research use only

This product is supplied strictly for laboratory research use only. It is not a drug, food, cosmetic or dietary supplement. It is not intended to diagnose, treat, cure or prevent any disease, and it is not intended for human or veterinary consumption or for administration to humans or animals in any form. It must be handled only by qualified researchers in an appropriate laboratory setting, and it is the purchaser who is responsible for ensuring that their intended use complies with all laws and institutional requirements that apply to them.