LL-37

Overview

LL-37 is the only cathelicidin derived antimicrobial peptide identified in humans, a 37 residue amphipathic sequence released from the C terminal end of the hCAP18 precursor protein. Its name comes from the two leucine residues at the N terminus and from its length. It is among the most studied host defence peptides in the literature, appearing in work on membrane interaction, bacterial and biofilm models and innate immune signalling, and it is frequently used as a reference sequence in structure activity studies across the cathelicidin family.

Areas of research interest

The points below describe where this material, or the compound class it belongs to, appears in the published scientific literature. They are provided to help researchers scope a study design. They are not claims about what this product does and no outcome of any kind is represented.

• Membrane interaction and pore formation studies
• Bacterial, biofilm and antimicrobial susceptibility models
• Innate immune signalling research in cell culture
• Structure activity work across the cathelicidin peptide family

Specifications

Handling, reconstitution and storage

• Store at 2 to 8 °C and protect from light unless the lot documentation states otherwise. Do not freeze.
• Inspect the vial before each withdrawal. Set the vial aside if the solution is discoloured, cloudy or contains particulate matter.
• Withdraw using aseptic technique and a fresh needle each time. Do not return withdrawn material to the vial.
• Record the date of first entry on the vial and establish an in-use period from your own stability testing.
• Use standard personal protective equipment and handle in an appropriate laboratory setting.

Certificate of Analysis

Every lot is supplied with its own Certificate of Analysis. Identity, content and purity figures are those stated on that document for the specific lot supplied, and researchers should verify identity and suitability against their own analytical methods before the material is put into a study.

Research use only

This product is supplied strictly for laboratory research use only. It is not a drug, food, cosmetic or dietary supplement. It is not intended to diagnose, treat, cure or prevent any disease, and it is not intended for human or veterinary consumption or for administration to humans or animals in any form. It must be handled only by qualified researchers in an appropriate laboratory setting, and it is the purchaser who is responsible for ensuring that their intended use complies with all laws and institutional requirements that apply to them.